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Marquette University

Academic institutionnorthamerica · us
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Research library14linked papers
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Selected work

Representative Papers

Clinical Feasibility of Low-Magnification Fluorescence Imaging for Breast Cancer Margin Detection Using Texture Analysis and Deep Learning

Aug 11, 2026

This study addresses the clinical need for efficient and accurate intraoperative assessment of breast cancer margins, where high-magnification imaging is often limited by small field-of-view and slow acquisition. For the first time, it systematically compares 4× and 10× MUSE fluorescence imaging performance, integrating Local Binary Pattern (LBP) texture analysis with Vision Transformer (ViT)-based deep learning for tissue classification. Results demonstrate that 4× imaging achieves 96.30% sensitivity, 100% specificity, and 98.18% accuracy under the ViT model, while LBP yields consistent 96.67% accuracy across both magnifications. These findings indicate that low-magnification imaging can deliver diagnostic accuracy comparable to high-magnification approaches while substantially improving field-of-view coverage and imaging speed, thereby enhancing practicality in intraoperative settings.

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Recent publications

Latest Papers

Clinical Feasibility of Low-Magnification Fluorescence Imaging for Breast Cancer Margin Detection Using Texture Analysis and Deep Learning

Aug 11, 2026

This study addresses the clinical need for efficient and accurate intraoperative assessment of breast cancer margins, where high-magnification imaging is often limited by small field-of-view and slow acquisition. For the first time, it systematically compares 4× and 10× MUSE fluorescence imaging performance, integrating Local Binary Pattern (LBP) texture analysis with Vision Transformer (ViT)-based deep learning for tissue classification. Results demonstrate that 4× imaging achieves 96.30% sensitivity, 100% specificity, and 98.18% accuracy under the ViT model, while LBP yields consistent 96.67% accuracy across both magnifications. These findings indicate that low-magnification imaging can deliver diagnostic accuracy comparable to high-magnification approaches while substantially improving field-of-view coverage and imaging speed, thereby enhancing practicality in intraoperative settings.

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