Scholar
Peter K. Sorger
Google Scholar ID: wS6Ii_cAAAAJ
Harvard Medical School
Citations & Impact
Citations
28,571
H-index
81
i10-index
265
Publications
20
Co-authors
47
list available
Contact
Publications
Resume (English only)
Academic Achievements
- Published multiple articles on FamPlex, a resource for entity recognition and relationship resolution of human protein families and complexes in biomedical text mining; explored the encoding of growth factor identity in the temporal dynamics of FOXO3 under the combinatorial control of ERK and AKT kinases; conducted a high-content screen in macrophages identifying small molecule modulators of STING-IRF3 and NFkB signaling; studied compensatory signaling responses to p38 inhibition in synovial fibroblasts primed by inflammatory but not mitogenic contexts; used multiplexed immunofluorescence to reveal potential PD-1/PD-L1 pathway vulnerabilities in craniopharyngioma; identified de novo nucleotide synthesis as a vulnerability of cells lacking SIRT3 through a small-molecule screen; discussed how combination cancer therapy can confer benefit via patient-to-patient variability without drug additivity or synergy; introduced the Library of Integrated Network-Based Cellular Signatures NIH Program: system-level cataloging of human cell response to perturbations; proposed moving from word models to executable models of signaling networks using automated assembly; quantified sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics.
Research Experience
- Engaged in research work at the Sorger Lab, Harvard Medical School; involved in the development of the NIH LINCS project, focusing on collecting and disseminating data on how human cells respond to perturbations by drugs, environmental factors, and mutations.
