Extending the Horizon of Early Diagnosis: Lung Cancer Prediction with Vision Transformers

2026-08-21

AI Summary

研究使用Vision Transformers预测早期肺癌，通过处理数据不平衡和采用预训练模型提高了预测性能，尽管未达临床应用标准，但支持进一步开发以标记高风险患者。

Abstract

Lung cancer remains a leading cause of cancer-related mortality worldwide, and early diagnosis is critical for improving survival. However, early-stage malignancies can be subtle on chest X-rays, creating challenges for radiologists. This study evaluates Vision Transformers (ViTs) for predicting lung cancer one to two years before clinical diagnosis. We analyzed 259,361 chest X-rays from 91,020 imaging studies at the Jamaica Plains VA Hospital in Boston, MA. The dataset showed extreme class imbalance, approximately 1:150 cancer to non-cancer, which was addressed using hybrid under- and over-sampling and class-weighted loss optimization. Three ViT configurations were evaluated: a model trained from scratch, an ImageNet-pretrained model, and a Corona-pretrained model fine-tuned on the lung cancer dataset. Transfer learning improved performance, with pretrained models exceeding the scratch baseline by 6-10 percentage points in AUC and about 10-12 percent in balanced accuracy. ImageNet-pretrained models showed the most stable overall performance, while Corona-pretrained models achieved higher sensitivity in some settings but greater variability. Moderate resampling ratios, including 1:1 undersampling and 1.5:2 oversampling, provided favorable trade-offs between sensitivity, precision, and computational efficiency, reducing runtime by up to 70 percent without major performance loss. These findings demonstrate the potential of ViTs for early lung cancer risk prediction from routine chest X-rays. Although performance remains below clinical deployment thresholds, the results support further development of ViT-based triage systems to flag high-risk patients for earlier evaluation.

Problem

• Lung Cancer
• Early Diagnosis
• Chest X-rays
• Vision Transformers
• Prediction

Innovation

• Vision Transformers
• early lung cancer prediction
• class imbalance
• transfer learning
• resampling