Agent4S: The Transformation of Research Paradigms from the Perspective of Large Language Models

📅 2025-06-30
📈 Citations: 0
Influential: 0
📄 PDF
🤖 AI Summary
Current AI for Science (AI4S) approaches remain largely task-specific, offering limited automation of end-to-end scientific workflows and lagging in paradigmatic evolution. Method: We propose Agent4S—a large language model (LLM)-based multi-agent system designed to support the full research lifecycle through autonomous, collaborative agent orchestration. Technically, it integrates LLM-driven agent architectures, programmable workflow engines, and distributed coordination mechanisms. Contribution/Results: We formally establish Agent4S as the fifth scientific paradigm—complementing experiment, theory, computation, and data—and introduce a five-level evolutionary taxonomy that systematically characterizes the progression of automated scientific discovery. This work lays the theoretical foundation and engineering infrastructure for autonomous scientific discovery systems, enabling a fundamental shift from tool-assisted to agent-native scientific practice.

Technology Category

Application Category

📝 Abstract
While AI for Science (AI4S) serves as an analytical tool in the current research paradigm, it doesn't solve its core inefficiency. We propose "Agent for Science" (Agent4S)-the use of LLM-driven agents to automate the entire research workflow-as the true Fifth Scientific Paradigm. This paper introduces a five-level classification for Agent4S, outlining a clear roadmap from simple task automation to fully autonomous, collaborative "AI Scientists." This framework defines the next revolutionary step in scientific discovery.
Problem

Research questions and friction points this paper is trying to address.

AI4S fails to address core inefficiencies in research workflows
Agent4S aims to automate entire scientific research using LLM-driven agents
Proposes a five-level roadmap for autonomous AI-driven scientific discovery
Innovation

Methods, ideas, or system contributions that make the work stand out.

LLM-driven agents automate research workflow
Five-level classification for Agent4S
Roadmap to autonomous AI Scientists
🔎 Similar Papers
No similar papers found.
B
Boyuan Zheng
Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China; Beijing Gongyu Zhiyan Technology Co., Ltd, Beijing, China
Z
Zerui Fang
School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Science, Beijing, China; Smart Sensing Chip and System R&D Center, Institute of Microelectronics of the Chinese Academy of Sciences, Beijing, China
Z
Zhe Xu
Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China; Key Laboratory of Material Physics, Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou, China
R
Rui Wang
School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Science, Beijing, China; Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China; Beijing Gongyu Zhiyan Technology Co., Ltd, Beijing, China
Yiwen Chen
Yiwen Chen
Ph.D. student, S-Lab, Nanyang Technological University
Computer Vision3D GenerationGenerative Models
C
Cunshi Wang
Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China; College of Astronomy and Space Sciences, University of Chinese Academy of Sciences, Beijing, China
M
Mengwei Qu
State Key Laboratory of Isotope Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, Guangdong China; College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing, China
L
Lei Lei
Alibaba Cloud, Hangzhou, Zhejiang, China
Z
Zhen Feng
College of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China
Y
Yan Liu
Department of science and development, Chinese academy of sciences, Beijing, China
Yuyang Li
Yuyang Li
Institute for AI, Peking University
Robotic ManipulationTactile SensingHuman-Object Interaction
M
Mingzhou Tan
Emotion Machine (Beijing) Technology Co., Ltd., Beijing, China
Jiaji Wu
Jiaji Wu
School of Electronic Engineering, Xidian University, Xi’an, Shaanxi, China
J
Jianwei Shuai
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China
J
Jia Li
Smart Sensing Chip and System R&D Center, Institute of Microelectronics of the Chinese Academy of Sciences, Beijing, China
F
Fangfu Ye
Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing, China