Generalist-Specialist Mixture-of-Experts for Rare Pathology Detection in Multimodal Imaging

📅 2026-09-16
📈 Citations: 0
Influential: 0
📄 PDF
🤖 AI Summary
为解决多模态医学影像中罕见病理检测问题,提出了一种结合跨模态通用模型和特定模态专家的GS-MoE架构,通过领域约束特征融合提高检测性能。
📝 Abstract
AI models for multimodal medical imaging must balance modality-specific specialization with cross-modal shared representations, a trade-off that pure Mixture-of-Experts (MoE) architectures currently fail to satisfy. Expert-based routing improves in-domain learning but may sacrifice cross-modal signals, which appear particularly important for rare (low-prevalence) pathologies in our experiments. To resolve this, we introduce Generalist-Specialist-MoE (GS-MoE), a two-branch (MoE) architecture that couples a cross-modal generalist model with distinct modality-specific specialists (experts) via domain-constrained feature fusion. On RadImageNet (1.35M images, 165 pathologies, three modalities), GS-MoE recovers detection of six low-prevalence pathologies on which every baseline scores F1 $=$ 0, with per-class gains up to +0.60 F1. It attains this while even slightly exceeding dense and specialist-only MoE aggregate baselines (MCC 0.770), while using ${\sim}53\%$ fewer active parameters at inference than the strongest investigated dense model.
Problem

Research questions and friction points this paper is trying to address.

Multimodal Medical Imaging
Mixture-of-Experts
Rare Pathology Detection
Cross-modal Shared Representations
Innovation

Methods, ideas, or system contributions that make the work stand out.

Generalist-Specialist Mixture-of-Experts
Cross-modal generalist
Modality-specific specialists
Domain-constrained feature fusion
Rare pathology detection
J
Johannes Kaiser
Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany
F
Florian Braunmiller
Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany
D
Daniel Rückert
Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany; Department of Computing, Imperial College London, UK
G
Georgios Kaissis
Hasso Plattner Institute for Digital Engineering, University of Potsdam, Potsdam, Germany