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University of Mississippi Medical Center

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Representative Papers

Covariate-Adjusted Functional Principal Components Analysis for Modeling Hazard Rates of Physical Activity in the US Population

Jun 17, 2026

Traditional summary metrics struggle to capture the heterogeneity in individual physical activity intensity distributions. This study proposes a novel approach that integrates wrist-worn accelerometer-derived individual activity intensity hazard functions with functional data analysis. By employing nonparametric modeling, log-transformation, and covariate-adjusted functional principal component analysis (FPCA), the method uncovers dominant modes of variation in population-level physical activity patterns. Moving beyond mean-based summaries, this framework offers a more flexible and interpretable characterization of heterogeneity. Applied to large-scale NHANES data, the approach successfully identifies significant differences in high- and low-intensity activity profiles across population subgroups, demonstrating its superior capability in describing and comparing physical activity distributions.

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Latest Papers

Covariate-Adjusted Functional Principal Components Analysis for Modeling Hazard Rates of Physical Activity in the US Population

Jun 17, 2026

Traditional summary metrics struggle to capture the heterogeneity in individual physical activity intensity distributions. This study proposes a novel approach that integrates wrist-worn accelerometer-derived individual activity intensity hazard functions with functional data analysis. By employing nonparametric modeling, log-transformation, and covariate-adjusted functional principal component analysis (FPCA), the method uncovers dominant modes of variation in population-level physical activity patterns. Moving beyond mean-based summaries, this framework offers a more flexible and interpretable characterization of heterogeneity. Applied to large-scale NHANES data, the approach successfully identifies significant differences in high- and low-intensity activity profiles across population subgroups, demonstrating its superior capability in describing and comparing physical activity distributions.

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