PRomop: A Decision-Ready Longitudinal Patient Health Record on the OMOP Common Data Model
This study addresses the challenges of fragmented medical data, storage-centric architectures, and redundant reconstruction of clinical states for downstream applications by proposing PRomop—a longitudinal patient health record representation grounded in the OMOP Common Data Model (CDM) version 5.4, extended with oncology-specific elements. PRomop compresses each patient’s complete clinical history into a single-row, 286-column decision-ready format through flat projection and precomputes key clinical states to enable efficient reuse while preserving full compatibility with OMOP standards. Deployed across two oncology institutions, the approach supports eligibility screening for 19,500 clinical trials; empirical evaluation on synthetic data demonstrates a 23.9-fold acceleration in trial matching and a 30- to 200-fold reduction in query complexity.