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Munich Data Science Institute

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Selected work

Representative Papers

International Transfer of Stochastic Cortical Self-Reconstruction

Aug 07, 2026

This study addresses the limitations of traditional cortical atrophy modeling—coarse regional granularity, reliance on covariates, and poor generalizability—by leveraging the Stochastic Cortical Self-Reconstruction (SCSR) framework. It presents the first validation of SCSR’s robust cross-population transferability, successfully generalizing from the UK Biobank cohort to a Chinese population. The approach employs vertex-level personalized healthy references, integrating a spherical U-Net (SUNet) with a multilayer perceptron for reconstruction, and incorporates fine-tuning strategies to enhance performance. The fine-tuned SUNet achieves state-of-the-art results with an average pairwise AUC of 0.848 and exhibits low reconstruction error across the full lifespan, significantly improving the detection of Alzheimer’s disease–related cortical atrophy in diverse populations.

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Latest Papers

International Transfer of Stochastic Cortical Self-Reconstruction

Aug 07, 2026

This study addresses the limitations of traditional cortical atrophy modeling—coarse regional granularity, reliance on covariates, and poor generalizability—by leveraging the Stochastic Cortical Self-Reconstruction (SCSR) framework. It presents the first validation of SCSR’s robust cross-population transferability, successfully generalizing from the UK Biobank cohort to a Chinese population. The approach employs vertex-level personalized healthy references, integrating a spherical U-Net (SUNet) with a multilayer perceptron for reconstruction, and incorporates fine-tuning strategies to enhance performance. The fine-tuned SUNet achieves state-of-the-art results with an average pairwise AUC of 0.848 and exhibits low reconstruction error across the full lifespan, significantly improving the detection of Alzheimer’s disease–related cortical atrophy in diverse populations.

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