Uncertainty-Aware and Explainable Ensemble Deep Learning Framework for Multi-Class Skin Lesion Classification
This study addresses the challenges of multi-class skin lesion classification in dermoscopic images—namely, high intra-class variability, inter-class similarity, class imbalance, and insufficient model interpretability—by proposing a deep ensemble framework that integrates MaxViT-Tiny with multiple convolutional neural networks (ConvNeXt-Tiny and EfficientNetV2-B0). To the best of our knowledge, this is the first work to apply MaxViT-Tiny to skin lesion classification. The framework incorporates Monte Carlo Dropout to quantify prediction uncertainty and employs Grad-CAM++ for visual interpretability. Evaluated on the HAM10000 dataset, the model achieves 96% accuracy, 99% ROC-AUC, and 95% macro-averaged precision, recall, and F1-score after uncertainty-based filtering, substantially enhancing diagnostic reliability and transparency.