Scholar
Ruth Nussinov
Google Scholar ID: L3n3n8UAAAAJ
Senior Principal Investigator, National Cancer Institute; Professor Emeritus, Tel Aviv University
Citations & Impact
Citations
30,501
H-index
82
i10-index
448
Publications
20
Co-authors
0
Publications
Resume (English only)
Academic Achievements
- Her 'conformational selection and population shift' idea as an alternative to the 'induced fit' textbook model explains the mechanism of molecular recognition. This concept has been confirmed by numerous experiments and is now widely established. For her contributions to the broad area of molecular recognition and allostery, she has been recognized as a Pioneer in Molecular Biology. She served as the Editor-in-Chief of PLOS Computational Biology and is currently Editor-in-Chief of Current Opinion in Structural Biology. Elected Fellow of the Biophysical Society, International Society of Computational Biology (ISCB), etc.
Research Experience
- Senior Investigator (Contr), Head of the Computational Structural Biology Section, member of the Cancer Innovation Laboratory. Main research areas include molecular recognition, allostery, and their roles in disease mechanisms.
Education
- Insufficient information provided
Background
- A biologist by training. Her dissertation proposed the dynamic programming algorithm for predicting the secondary structure of single stranded RNA, which is still the leading method for RNA folding to this date. Her most important discovery was in the 1990s, proposing that all conformations preexist and that evolution harnesses their dynamic interconversion for function, dispelling the dogma that only the wild-type shape is relevant.
Co-authors