Completed reference-quality genome assemblies of three Candida auris clade strains (2024)
Published on PfAP2-P’s role in malaria parasite pathogenesis in Nature Microbiology (2023)
Published MIST technology in npj Systems Biology and Applications (2024)
Developed the first single-cell isoform sequencing protocol capturing full-length transcripts
Built one of the world’s largest RNA-seq datasets from postmortem lungs of COVID-19 patients
Authored multiple high-impact publications (e.g., Gupta et al. 2014; Gupta & Villanyi et al. 2016; Raj et al. 2018; Kapoor et al. 2019; Bhatia & Makhija et al. 2022)
Research Experience
Leads the Gupta Lab at IIT Delhi as Principal Investigator
Contributing to the national GenomeIndia initiative by performing de novo assembly of mitochondrial genomes to build the first Indian mitochondrial reference genome
Research areas include cellular heterogeneity in host-pathogen interactions, molecular mechanisms of cancer persistence and immunotherapy, and functional consequences of genetic diversity in India
Developed Microarray Integrated Spatial Transcriptomics (MIST) for affordable digital pathology
Generated the first single-cell RNA-seq dataset from India
Conducted large-scale RNA-seq analysis on postmortem lung tissues from COVID-19 patients
Background
Faculty at Department of Biochemical Engineering and Biotechnology, IIT Delhi, India
Principal Investigator of the Functional Genomics Lab
Develops and applies omics technologies with high resolution (single-cell), high precision (isoforms), and high throughput (hundreds to millions of samples)
Focuses on dissecting biological complexity in the contexts of evolution and disease
Develops AI-based genomics solutions for precision diagnostics