Scholar
Samuel Aparicio
Google Scholar ID: CDzkouoAAAAJ
UBC, BC Cancer Agency, Vancouver
Citations & Impact
Citations
40,597
H-index
83
i10-index
198
Publications
20
Co-authors
25
list available
Contact
Publications
Resume (English only)
Academic Achievements
- Recent publications include:
- “Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations” (Dec 11, 2024)
- “Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment” (Jun 20, 2024)
- “Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes” (May 16, 2024)
- “Disentangling oncogenic amplicons in esophageal adenocarcinoma” (May 15, 2024)
Research Experience
- Principal investigator of the Aparicio Lab located at BC Cancer Agency, Vancouver
- Conducts research on cancer evolution through temporal and spatial multi-sample studies
- Tracks clonal dynamics via time-series biopsies, patient-derived xenografts (PDX), and anatomical spread of clones
- Pioneers single-cell genomics using optimized biophysical techniques and hidden Markov models for accurate copy number profiling
- Develops phylogenetic and fitness computational models to analyze population dynamics of thousands of cancer cells under genetic or pharmacologic perturbations
Background
- Leads an international cancer biology and genomics lab
- Dedicated to dissecting fundamental properties of cancer evolution and developing novel therapies
- Uses high-resolution genomics and genetics to study human cancers
- Integrates innovative computational methods to infer cancer biology at genome and single-cell scales
- Translates research findings into new cancer therapeutics
