Developed pathology foundation models UNI (published in Nature Medicine) and CONCH (published in Nature Medicine).
Created PathChat, a generative AI chatbot/multimodal large language model for human pathology (published in Nature).
PathChat DX, the clinical-grade version of PathChat, received FDA Breakthrough Device Designation—among the first generative AI tools in pathology to do so.
Introduced KRONOS, a foundation model for spatial proteomics.
Proposed VORTEX, an AI-driven 3D spatial transcriptomics method.
Released open-source libraries TRIDENT (for large-scale WSI batch processing) and Patho-Bench (for foundation model benchmarking).
Proposed THREADS, a molecular-driven foundation model for pathology.
Published a paper on transferability of MIL models at ICML 2025.
Published a commentary on benchmarking in machine learning for biomedicine in Nature Medicine.
PhD student Cristina Almagro-Pérez awarded the prestigious Rafael del Pino Foundation Fellowship.
Background
Develops machine learning, data fusion, and medical image analysis methods for objective diagnosis, prognosis, and biomarker discovery.
Focuses on using AI as an assistive tool for pathologists to reduce interobserver and intraobserver variability in cancer diagnosis.
Develops novel algorithms to identify clinically relevant morphologic phenotypes and biomarkers associated with response to specific therapeutics.
Builds multimodal fusion algorithms integrating imaging modalities, patient/family histories, and multi-omics data for precise diagnostic, prognostic, and therapeutic decisions.
Affiliated with the Harvard Data Science Initiative, Harvard Bioinformatics and Integrative Genomics (BIG) program, Dana-Farber Cancer Institute’s Cancer Data Science Program, and the Cancer Program at the Broad Institute of Harvard and MIT.