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Academic Achievements
Sha Cao awarded the NIGMS R35 grant to develop a systems biology framework for dissecting crosstalk among cellular components in disease tissue microenvironments (Oct 2024)
Sha Cao awarded the American Cancer Society Research Scholar Grant supporting her research on breast and pancreatic cancer (Oct 2024)
Chi Zhang awarded an R01 grant using AI-empowered wearable multimodal sensors for noninvasive monitoring of Parkinson’s disease (Sep 2024)
Sha Cao presented a poster titled “Computational methods to study metabolic variations in PDAC” at the AACR Pancreatic Cancer Meeting 2024 in Boston (Sep 2024)
Collaborative work with Dr. Xinna Zhang’s group, “Inhibition of Glutamate-to-Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells,” accepted by Advanced Science (Sep 2024)
Collaborative paper “A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells” accepted by PNAS (May 2024)
Jia Wang received a $10k IUSCCC Training Grant for “Computational Modeling of MHC-I antigen presentation flow in cancer cells” (May 2024)
Chi Zhang invited by NIH Innovation Lab to participate in a five-day closed-door expert workshop on quantum computing applications in biomedical research (Oct 2024)
Sha Cao gave talks on “Integrating multi-omics data for sparse latent space detection” at ICSA China (Wuhan) and ISGTM (Xi’an) in June 2024
Background
Research interests include understanding mathematical representations of biological processes, relations, and functions in omics data and developing underlying analysis principles and mathematical theories
Developing new systems biology models and AI frameworks to maximize understanding of biological mechanisms in omics and multi-omics data
Representation learning of high-dimensional data, with a focus on linear/non-linear low-rank and local low-rank representation of matrices and high-order tensors
Understanding biochemical variations in the microenvironment of cancer and inflammatory diseases
Developing explainable graphical/network models for biomedical data and transfer learning
Studying single-cell and spatial multi-omics data to infer sample-wise/spatial-dependent activity of transcriptional regulation, metabolism, and signaling pathways
Biomarker prediction and development of personal wearable sensors and other smart health-related AI and biotechnologies
Natural language processing-based mining of biological literature data