Identifying Causal Effects Using a Single Proxy Variable

πŸ“… 2026-04-10
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This study addresses the challenge of identifying causal effects in the presence of unobserved confounders by introducing the SPICE condition, which ensures identifiability under the assumption that only a single observed proxy variable is available and its generative mechanism is known. Building on this condition, the authors develop SPICE-Net, a general-purpose neural network framework capable of handling both discrete and continuous treatment variables. The work substantially extends existing proxy-based identification theory to high-dimensional settings, nonlinear functional relationships, and broader distributional classes. It presents the first learnable, end-to-end approach to causal identification and estimation grounded in the completeness assumption, provides rigorous theoretical proof of identifiability under the SPICE condition, and empirically demonstrates the method’s effectiveness across diverse treatment types.

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πŸ“ Abstract
Unobserved confounding is a key challenge when estimating causal effects from a treatment on an outcome in scientific applications. In this work, we assume that we observe a single, potentially multi-dimensional proxy variable of the unobserved confounder and that we know the mechanism that generates the proxy from the confounder. Under a completeness assumption on this mechanism, which we call Single Proxy Identifiability of Causal Effects or simply SPICE, we prove that causal effects are identifiable. We extend the proxy-based causal identifiability results by Kuroki and Pearl (2014); Pearl (2010) to higher dimensions, more flexible functional relationships and a broader class of distributions. Further, we develop a neural network based estimation framework, SPICE-Net, to estimate causal effects, which is applicable to both discrete and continuous treatments.
Problem

Research questions and friction points this paper is trying to address.

unobserved confounding
causal effects
proxy variable
causal identifiability
SPICE
Innovation

Methods, ideas, or system contributions that make the work stand out.

causal identifiability
proxy variable
unobserved confounding
SPICE
neural estimation
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