Bias and Coverage Properties of the WENDy-IRLS Algorithm

📅 2025-10-03
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This study systematically evaluates the statistical performance of the WENDy-IRLS algorithm for joint parameter and state estimation in nonlinear ordinary differential equations (ODEs), using five benchmark systems: Logistic, Lotka–Volterra, FitzHugh–Nagumo, Hindmarsh–Rose, and Protein Transduction. We conduct large-scale simulations under four nonstandard noise regimes—Gaussian, log-normal, additive censored normal, and additive truncated normal—at high noise levels. As the first comprehensive statistical analysis of WENDy-IRLS, we rigorously assess estimator bias and confidence interval coverage. Results demonstrate that the synergy between the weak-form estimation framework and iterative reweighted least squares (IRLS) substantially enhances robustness against heteroscedasticity, non-Gaussianity, and censoring/truncation effects. Even under severe noise, the algorithm achieves low bias and near-nominal coverage, establishing it as a reliable tool for uncertainty quantification in complex dynamical systems.

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📝 Abstract
The Weak form Estimation of Nonlinear Dynamics (WENDy) method is a recently proposed class of parameter estimation algorithms that exhibits notable noise robustness and computational efficiency. This work examines the coverage and bias properties of the original WENDy-IRLS algorithm's parameter and state estimators in the context of the following differential equations: Logistic, Lotka-Volterra, FitzHugh-Nagumo, Hindmarsh-Rose, and a Protein Transduction Benchmark. The estimators' performance was studied in simulated data examples, under four different noise distributions (normal, log-normal, additive censored normal, and additive truncated normal), and a wide range of noise, reaching levels much higher than previously tested for this algorithm.
Problem

Research questions and friction points this paper is trying to address.

Analyzes bias and coverage of WENDy-IRLS parameter estimators
Evaluates algorithm performance under four different noise distributions
Tests parameter estimation robustness at high noise levels
Innovation

Methods, ideas, or system contributions that make the work stand out.

Weak form estimation of nonlinear dynamics
IRLS algorithm for parameter estimation
Noise robustness across multiple distributions
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A
Abhi Chawla
Department of Applied Mathematics, University of Colorado, Boulder, CO, 80309-0526, USA
D
David M. Bortz
Department of Applied Mathematics, University of Colorado, Boulder, CO, 80309-0526, USA
Vanja Dukic
Vanja Dukic
Professor of Applied Mathematics, University of Colorado at Boulder
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