Right Diagnoses, Decorative Reasoning:A Perturbation Audit of Medical Chain-of-Thought

📅 2026-08-25
📈 Citations: 0
Influential: 0
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🤖 AI Summary
研究通过临床扰动审计方法,测试医学链式思维的忠实性,发现大多数模型中链式思维与答案脱节,即使修改链式内容也不影响答案准确性。
📝 Abstract
Clinicians read chain-of-thought (CoT) rationales as evidence of medical reasoning, but whether the visible chain plays that role is rarely tested. General-domain CoT-faithfulness probes ignore clinical cost, and medical LLM evaluations treat the chain as a black box. We close this gap with a medical perturbation audit: a 30-operator battery edits both the chain and the question with clinically motivated operators (severity reversal, negation flip, demographic swap, evidence ablation), paired with a chain-update times answer-flip joint analysis that classifies each model by its failure mode. Applied to 14 LLMs on four medical QA benchmarks, three independent tests converge: the Chain-Decoupling Rate (CDR; chain does not register the edit and the answer does not flip) is 72.9% panel-wide on clinically meaningful destructive edits, chain corruption leaves accuracy unchanged, and removing CoT prompting does not reduce accuracy. Two board-certified clinicians re-annotate N=197 perturbed questions; 98.5% leave the gold defensible. The pattern holds across medical and reasoning fine-tuning and scale; on the closed-source tier, where the chain text is unavailable, the answer-side signals are consistent with the same decoupling. Our framework and CDR provide a reusable yardstick for auditing whether medical CoT is faithful or merely documentation.
Problem

Research questions and friction points this paper is trying to address.

Medical Chain-of-Thought
Faithfulness
Clinical Reasoning
Innovation

Methods, ideas, or system contributions that make the work stand out.

Perturbation Audit
Chain-of-Thought
Clinical Reasoning
Chain-Decoupling Rate (CDR)
M
Mengzhu Xu
Eindhoven University of Technology, Eindhoven, The Netherlands
J
Jifan Gao
Dana-Farber Cancer Institute, Boston, MA, USA
X
Xia Jiang
Eindhoven University of Technology, Eindhoven, The Netherlands
Yaoxin Wu
Yaoxin Wu
Eindhoven University of Technology
Deep learningCombinatorial optimizationInteger programmingMulti-objective optimization
Xi Long
Xi Long
Eindhoven University of Technology, Eindhoven, The Netherlands