A practical artificial intelligence framework for legal age estimation using clavicle computed tomography scans

📅 2026-03-18
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🤖 AI Summary
This study addresses the lack of high-precision, interpretable, and uncertainty-quantifying methods for clavicular CT-based age estimation in forensic science. The authors propose the first end-to-end framework integrating explainable artificial intelligence with conformal prediction: clavicles are automatically localized via connected-component detection, key slices are selected using Integrated Gradients, and a multi-slice CNN performs age regression, with conformal prediction generating internationally compliant prediction intervals that quantify uncertainty. Evaluated on 1,158 postmortem CT scans, the method achieves a mean absolute error of 1.55 ± 0.16 years—significantly outperforming both human experts (≈1.90 years) and existing approaches (>1.75 years). The system has been integrated into the Skeleton-ID software as a forensic decision-support module.

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📝 Abstract
Legal age estimation plays a critical role in forensic and medico-legal contexts, where decisions must be supported by accurate, robust, and reproducible methods with explicit uncertainty quantification. While prior artificial intelligence (AI)-based approaches have primarily focused on hand radiographs or dental imaging, clavicle computed tomography (CT) scans remain underexplored despite their documented effectiveness for legal age estimation. In this work, we present an interpretable, multi-stage pipeline for legal age estimation from clavicle CT scans. The proposed framework combines (i) a feature-based connected-component method for automatic clavicle detection that requires minimal manual annotation, (ii) an Integrated Gradients-guided slice selection strategy used to construct the input data for a multi-slice convolutional neural network that estimates legal age, and (iii) conformal prediction intervals to support uncertainty-aware decisions in accordance with established international protocols. The pipeline is evaluated on 1,158 full-body post-mortem CT scans from a public forensic dataset (the New Mexico Decedent Image Database). The final model achieves state-of-the-art performance with a mean absolute error (MAE) of 1.55 $\pm$ 0.16 years on a held-out test set, outperforming both human experts (MAE of approximately 1.90 years) and previous methods (MAEs above 1.75 years in our same dataset). Furthermore, conformal prediction enables configurable coverage levels aligned with forensic requirements. Attribution maps indicate that the model focuses on anatomically relevant regions of the medial clavicular epiphysis. The proposed method, which is currently being added as part of the Skeleton-ID software (https://skeleton-id.com/skeleton-id/), is intended as a decision-support component within multi-factorial forensic workflows.
Problem

Research questions and friction points this paper is trying to address.

legal age estimation
clavicle CT scans
forensic
uncertainty quantification
artificial intelligence
Innovation

Methods, ideas, or system contributions that make the work stand out.

clavicle CT
legal age estimation
interpretable AI
conformal prediction
Integrated Gradients
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J
Javier Venema
Panacea Cooperative Research S.Coop., C. Ramón y Cajal, 33, Ponferrada, 24400, Spain; Department of Computer Science and Artificial Intelligence, University of Granada, C. Periodista Daniel Saucedo Aranda, Granada, 18071, Spain; Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI Institute), Av. del Conocimiento, 37, Granada, 18037, Spain
S
Stefano De Luca
Department of Organisms and Systems Biology, Faculty of Biology, University of Oviedo, C. Catedrático Rodrigo Uria, Oviedo, 33066, Spain
Pablo Mesejo
Pablo Mesejo
Associate Professor, University of Granada & chief AI officer, Panacea Cooperative Research
Computer VisionMachine LearningArtificial IntelligenceBiomedical Image Analysis
Ó
Óscar Ibáñez
Faculty of Computer Science, CITIC, University of A Coruña, Campus de Elviña, A Coruña, 15071, Spain; Panacea Cooperative Research S.Coop., C. Ramón y Cajal, 33, Ponferrada, 24400, Spain