A Reproducible Log-Driven AutoML Framework for Interpretable Pipeline Optimization in Healthcare Risk Prediction

πŸ“… 2026-05-19
πŸ“ˆ Citations: 0
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πŸ€– AI Summary
This work addresses the challenges of model accuracy and reproducibility in medical risk prediction arising from heterogeneous features, scarce samples, and severe class imbalance. The authors propose the yvsoucom-iterkit framework, which innovatively encodes AutoML pipelines as traceable log entities to construct a log-driven, deterministic optimization system. By leveraging configuration-level logs, the method enables component attribution, interaction analysis, and robustness evaluation across random seeds, revealing structured redundancies in the search space and identifying a small set of high-impact components that dominate overall performance. Experiments on the Pima and Stroke datasets demonstrate that optimizing only these critical components achieves Weighted-F1 scores of 0.89 and 0.94, respectively, with ensemble models exhibiting minimal performance variance (0.023–0.026) across random seeds, thereby validating the approach’s effectiveness and stability.
πŸ“ Abstract
Accurate and reproducible disease risk prediction remains challenging due to heterogeneous features, limited samples, and severe class imbalance. This study introduces yvsoucom-iterkit, a deterministic and log-driven automated machine learning framework that formulates pipeline optimization as a fully reproducible, configuration-level system. Each pipeline is encoded as a traceable log entity, enabling analysis of component attribution, interactions, similarity, and cross-seed robustness. Experiments on the Pima Indians Diabetes and Stroke datasets across more than 18,000 pipeline configurations reveal a structured and partially redundant search space, where performance is governed by a small subset of interacting components. Random Forest importance analysis identifies augmentation (0.454), model choice (0.198), and imbalance handling (0.101) as key drivers on Pima, while imbalance handling dominates Stroke (0.406). Component similarity analysis shows strong redundancy, with feature selection variants (biMax-biMean) exhibiting low RMS distance (0.0252), mixup closely matching no augmentation (0.0279), and TomekLinks aligning with no imbalance handling (0.0325), whereas Gaussian noise shows greater divergence from no augmentation (0.10). The framework achieves strong and stable performance using ensemble models (Weighted-F1 0.89, Macro-F1 0.88 on Pima; Weighted-F1 0.94 on Stroke), while Macro-F1 remains lower on Stroke (0.67) due to class imbalance. Cross-seed analysis reveals a performance-robustness trade-off, with ensembles showing lower variability (0.023-0.026) than SVM. These results indicate that effective AutoML optimization can focus on a reduced set of high-impact components.
Problem

Research questions and friction points this paper is trying to address.

healthcare risk prediction
class imbalance
reproducibility
heterogeneous features
limited samples
Innovation

Methods, ideas, or system contributions that make the work stand out.

log-driven AutoML
reproducible pipeline optimization
component attribution
cross-seed robustness
interpretable AutoML
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