A Source-Grounded Framework for Constructing and Evaluating Progressive Multimodal Diagnostic Dialogues from Clinical Case Reports

📅 2026-08-23
📈 Citations: 0
Influential: 0
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🤖 AI Summary
本文提出一种基于源的框架,用于从病例报告中构建和评估渐进式多模态诊断对话,解决现有方法无法有效整合逐步临床证据的问题。
📝 Abstract
Clinical diagnosis requires progressive integration of patient history, physical examination, laboratory findings, medical images, and diagnostic-informative tests. However, most multimodal medical benchmarks evaluate fixed inputs or endpoint answers, while fully interactive diagnostic agents conflate evidence selection with evidence interpretation. We present a source-grounded framework to construct progressive multimodal diagnostic dialogues from case reports and an evaluation strategy for assessing MLLMs on final diagnosis, diagnostic reasoning, and image-finding interpretation. Evaluation on 24 internal medicine case reports showed that our framework can accurately convert case reports into reference dialogues, achieving a diagnosis F1 of 0.99 and a reasoning-quality score of 4.79 out of 5. Evaluation on two frontier MLLMs (o4-mini and Claude Haiku 4.5) achieved reasoning-quality scores of 2.75 and 2.50, respectively, with substantially lower diagnosis, reasoning, and image-finding F1 scores. The results demonstrate that fluent responses do not necessarily reflect evidence-grounded clinical reasoning and highlight the utility of the proposed framework for evaluating multimodal diagnostic reasoning.
Problem

Research questions and friction points this paper is trying to address.

multimodal diagnostic dialogues
clinical case reports
evidence integration
diagnostic reasoning
evaluation framework
Innovation

Methods, ideas, or system contributions that make the work stand out.

source-grounded framework
multimodal diagnostic dialogues
clinical reasoning evaluation
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