Numerical Simulation of Transdermal Insulin Delivery Using a Coated Microneedle in a 2D Skin Model

2026-09-16

AI Summary

本文通过建立包含涂层微针的2D皮肤模型，模拟并分析了胰岛素经皮递送过程及其在各皮肤层中的分布情况。

Abstract

In this work, we present a computational model to investigate transdermal insulin delivery using coated microneedles. A detailed skin geometry incorporating a coated microneedles was developed to analyze insulin release through the different skin layers and to evaluate the influence of key transport parameters. The model represents the major skin layers: the stratum corneum, viable epidermis, and dermis. Unstructured grids were used to achieve a reliable resolution of the model. The simulations provide insights into the permeation of insulin from the coated microneedles and the transport and distribution across the different skin layers. Finally, the simulation results were compared with experimental data to evaluate the predictive capability of the model.

Problem

• transdermal insulin delivery
• coated microneedles
• skin layers
• transport parameters

Innovation

• transdermal insulin delivery
• coated microneedles
• computational model
• skin layers
• unstructured grids