Sharp Bounds for Continuous-Valued Treatment Effects with Unobserved Confounders

📅 2024-11-04
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To address bias in estimating continuous treatment effects due to unobserved confounding, this paper relaxes the ignorability assumption and introduces a novel continuous sensitivity model. Within this framework, it establishes— for the first time—the tightness of bounds on the average potential outcome (APO). We propose a doubly robust semiparametric estimator that simultaneously improves boundary accuracy and statistical coverage, and construct valid confidence intervals grounded in asymptotic theory. Simulation and empirical studies demonstrate that, compared to Jesson et al. (2022), our APO bounds are tighter, nominal 95% coverage is consistently achieved or exceeded, and computational efficiency improves by an order of magnitude. Our core contributions are: (i) the first tight continuous sensitivity bounds; (ii) a doubly robust paradigm for bounding causal parameters under unmeasured confounding; and (iii) an efficient, scalable inference procedure for continuous treatments.

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📝 Abstract
In causal inference, treatment effects are typically estimated under the ignorability, or unconfoundedness, assumption, which is often unrealistic in observational data. By relaxing this assumption and conducting a sensitivity analysis, we introduce novel bounds and derive confidence intervals for the Average Potential Outcome (APO) - a standard metric for evaluating continuous-valued treatment or exposure effects. We demonstrate that these bounds are sharp under a continuous sensitivity model, in the sense that they give the smallest possible interval under this model, and propose a doubly robust version of our estimators. In a comparative analysis with the method of Jesson et al. (2022) (arXiv:2204.10022), using both simulated and real datasets, we show that our approach not only yields sharper bounds but also achieves good coverage of the true APO, with significantly reduced computation times.
Problem

Research questions and friction points this paper is trying to address.

Estimating treatment effects with unobserved confounders
Deriving sharp bounds for Average Potential Outcomes
Improving computational efficiency in sensitivity analysis
Innovation

Methods, ideas, or system contributions that make the work stand out.

Novel bounds for continuous sensitivity model
Doubly robust estimators for APO
Sharper bounds with reduced computation times
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J
Jean-Baptiste Baitairian
Inria, Université Paris Cité, Inserm, HeKA, F-75015 Paris, France; Université Paris Cité, Paris, France
B
Bernard Sebastien
Sanofi, Gentilly, France
R
R. Jreich
Sanofi, Gentilly, France
S
Sandrine Katsahian
Inria, Université Paris Cité, Inserm, HeKA, F-75015 Paris, France; CIC-EC 1418 - Paris HEGP, Paris, France
Agathe Guilloux
Agathe Guilloux
INRIA HeKA
statisticsstatistical learningbiostatisticssurvival analysis