Exemplar: Classical Priors Complement Frozen Features for Few-Shot Microscopy Segmentation at Native Resolution

📅 2026-09-02
📈 Citations: 0
Influential: 0
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🤖 AI Summary
本文提出Exemplar,通过结合冻结的DINOv3主干和经典滤波器响应来解决少量标注下的生物医学图像分割问题,提高了分割精度和效率。
📝 Abstract
Segmenting a new biomedical dataset usually means a domain-specific model trained on substantial annotation, or a foundation model steered at inference time. We present Exemplar, a few-shot segmenter that fuses a frozen DINOv3 backbone with a fixed bank of classical native-resolution filter responses in one lightweight head, fitted from the support masks alone. In the few-mask, native-resolution regime, classical priors and frozen self-supervised features are complementary: fused in one head, a single fixed configuration spans eleven biomedical imaging datasets. Under the same head, the classical bank alone reaches 0.693 on the eleven-dataset panel, scored by foreground intersection-over-union or centreline Dice, and the frozen features alone 0.672; the bank leads on seven of the eleven and the features on the rest, and fused they reach 0.782. Against five forward-pass few-shot methods, Exemplar leads in 54 of 55 method-dataset comparisons, 52 of them significant after Holm correction. From a single annotated mask it reaches 0.703 on the same panel, against 0.682 for a from-scratch nnU-Net trained on that same mask. At eight masks nnU-Net overtakes it on the panel mean, chiefly on centreline agreement, but takes 16-77x longer to fit.
Problem

Research questions and friction points this paper is trying to address.

few-shot segmentation
biomedical imaging
native resolution
frozen features
classical priors
Innovation

Methods, ideas, or system contributions that make the work stand out.

few-shot segmentation
frozen DINOv3 backbone
classical priors
native resolution
lightweight head
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Michal Průšek
The Czech Academy of Sciences, Institute of Information Theory and Automation, Czechia; Czech Technical University in Prague, Faculty of Nuclear Sciences and Physical Engineering, Czechia
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Adam Novozámský
The Czech Academy of Sciences, Institute of Information Theory and Automation, Czechia
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Filip Šroubek
The Czech Academy of Sciences, Institute of Information Theory and Automation, Czechia