Semi-Supervised Learning-Based Genetic Biomarkers Dataset for Multiple-Stage Hepatocellular Carcinoma Prediction

2026-09-15

AI Summary

本文通过结合XGBoost与半监督学习方法，构建了一个包含770个样本的多阶段肝细胞癌(HCC)基因生物标志物数据集，以提高HCC分类精度。

Abstract

Liver cancer is a complex disease responsible for a high number of deaths across the globe each year, making automated solutions for liver cancer classification urgent. The most common form of liver cancer is hepatocellular carcinoma (HCC), accounting for over 90% of liver cancer cases. There is a distinct lack of publicly available HCC datasets utilizing genomic data, which is necessary for training artificial intelligence (AI) models for automated HCC classification. This study proposes constructing a multi-stage HCC dataset using XGBoost and Semi-Supervised learning on three separate datasets of genomic biomarkers, utilizing their existing labels in the Semi-Supervised learning process to label the proposed dataset. The proposed dataset consists of 770 patient samples in total, categorized into five classes that represent normal tissue alongside different stages of HCC. Each sample in the dataset consists of 11,150 different gene expression levels. The XGBoost model demonstrated a final classification accuracy of 96.5% during the Semi-Supervised learning process.

Problem

• Hepatocellular Carcinoma
• Genomic Data
• Semi-Supervised Learning
• Dataset Construction

Innovation

• Semi-Supervised Learning
• XGBoost
• Genetic Biomarkers
• Hepatocellular Carcinoma
• Multi-Stage Dataset