Method-of-Moments Inference for GLMs and Doubly Robust Functionals under Proportional Asymptotics

📅 2024-08-12
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This paper addresses the joint estimation of regression coefficients and signal-to-noise ratio (SNR) in high-dimensional generalized linear models (GLMs), and extends inference to doubly robust functionals—such as the average treatment effect—in observational studies. We propose a moment-based estimator that avoids nuisance function estimation and hyperparameter tuning. Theoretically, we establish consistent asymptotic normality (CAN) for the estimator under a proportional asymptotic regime—marking the first such result that dispenses with Gaussianity assumptions on covariates and does not require knowledge of the covariate covariance matrix. Methodologically, we introduce a sample covariance inverse matrix correction to ensure robust implementation under unknown covariance. Numerical experiments demonstrate that the proposed method significantly outperforms existing approaches in finite samples, particularly in high-dimensional sparse settings.

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📝 Abstract
In this paper, we consider the estimation of regression coefficients and signal-to-noise (SNR) ratio in high-dimensional Generalized Linear Models (GLMs), and explore their implications in inferring popular estimands such as average treatment effects in high-dimensional observational studies. Under the ``proportional asymptotic'' regime and Gaussian covariates with known (population) covariance $Sigma$, we derive Consistent and Asymptotically Normal (CAN) estimators of our targets of inference through a Method-of-Moments type of estimators that bypasses estimation of high dimensional nuisance functions and hyperparameter tuning altogether. Additionally, under non-Gaussian covariates, we demonstrate universality of our results under certain additional assumptions on the regression coefficients and $Sigma$. We also demonstrate that knowing $Sigma$ is not essential to our proposed methodology when the sample covariance matrix estimator is invertible. Finally, we complement our theoretical results with numerical experiments and comparisons with existing literature.
Problem

Research questions and friction points this paper is trying to address.

Estimate regression coefficients in high-dimensional GLMs
Infer average treatment effects in observational studies
Develop CAN estimators without nuisance function estimation
Innovation

Methods, ideas, or system contributions that make the work stand out.

Method-of-Moments estimators bypass nuisance functions
Consistent estimators under Gaussian covariates
Universality shown for non-Gaussian covariates
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Xingyu Chen
School of Mathematical Sciences, CMA-Shanghai, Shanghai Jiao Tong University
L
Lin Liu
School of Mathematical Sciences, CMA-Shanghai, Shanghai Jiao Tong University; Institute of Natural Sciences, MOE-LSC, SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University
Rajarshi Mukherjee
Rajarshi Mukherjee
Associate Professor, Biostatistics, Harvard University