LabAgent: Customize Any Research Hubs for Scientific Discoveries Using AI Agents

📅 2026-09-11
📈 Citations: 0
Influential: 0
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🤖 AI Summary
为解决实验室人员变动导致方法无法延续的问题,提出LabAgent系统,通过记录和验证技能来保证知识的传承与扩展。
📝 Abstract
Scientific research is a continuous process that emphasizes inheritance. Methods developed by predecessors are often expanded upon by new researchers to explore more novel and in-depth scientific questions. However, the change of lab staff, such as student graduation, leads to a lack of personnel capable of replicating methods. Methods that have been developed with significant effort and resources cannot be continued. To address these limitations, we propose LabAgent, a reproduce and discovery harness tailored for a lab's continuous work. LabAgent employs two mechanisms to guarantee that all skills can be executed and verified and to record the corrective methods and experiences, allowing for direct correction or avoidance of similar errors. We applied LabAgent to drug property prediction, biomedical problem analysis, protein variant effect prediction, and statistical genetics in life science domains. LabAgent ranks first over commercial generalist agents in every domain, and demonstrates accurate reproduction of a published figure. Overall, these results demonstrate that LabAgent can effectively integrate and reasonably expand laboratory knowledge.
Problem

Research questions and friction points this paper is trying to address.

Scientific Research
Knowledge Inheritance
Laboratory Staff Change
Method Replication
Innovation

Methods, ideas, or system contributions that make the work stand out.

AI Agents
Skill Reproduction
Knowledge Integration
Error Correction Mechanism
Lei Liu
Lei Liu
Professor of Biostatistics, Washington University
Biostatistics and Data Science
Y
Yikun Zhang
Department of Computer Science, Northeastern University; EWSC Center, Broad Institute of MIT and Harvard
Jialin Chen
Jialin Chen
Yale University
Foundation ModelsGraph LearningMultimodal RAG
Wanjia Zhao
Wanjia Zhao
Stanford University
Machine Learning
R
Rex Ying
Department of Computer Science, Yale University
W
Wengong Jin
Department of Computer Science, Northeastern University; EWSC Center, Broad Institute of MIT and Harvard
H
Hua Xu
Interdepartmental Program in Computational Biology and Bioinformatics, Yale University; Department of Biomedical Informatics and Data Science, Yale University
James Zou
James Zou
Stanford University
Machine learningcomputational biologycomputational healthstatisticsbiotech
Tianyu Liu
Tianyu Liu
Yale University
Machine learningBiostatistics
Hongyu Zhao
Hongyu Zhao
Yale University
First interestSecond interest