A Self-Evolving Agent for Longitudinal Personal Health Management

📅 2026-07-15
📈 Citations: 0
Influential: 0
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🤖 AI Summary
This work addresses the limitations of existing health AI systems, which typically operate through isolated interactions and struggle to adapt to users’ evolving health states and preferences over time. The authors propose HealthClaw, the first longitudinal personal health management agent architecture featuring a controlled self-evolving memory mechanism. Through a modular design that decouples shared safety rules, medical knowledge, and private longitudinal memory, HealthClaw dynamically updates user profiles and enables reusable interaction workflows while preserving accuracy, privacy, and safety. Empirical results demonstrate substantial improvements: across 900 longitudinal interactions, task accuracy increased from 0.2% to 45.7%, with a 71.7% reduction in prompt context exposure. Furthermore, HealthClaw achieved an average performance gain of 27.0 percentage points across nine biomedical tasks—seven of which remained statistically significant after multiple-testing correction—and exhibited superior privacy preservation in 100 dedicated privacy evaluations.
📝 Abstract
Personal health management unfolds over repeated encounters, yet most health AI systems treat each request in isolation. We developed HealthClaw, an open-source agent architecture that updates support as a person's routines, preferences, measurements and risks change. It separates shared safety rules and medical knowledge from private longitudinal memory containing profile facts, reusable procedures and episodic traces. After each episode, induction determines what should update the profile, revise a procedure, remain episodic or be excluded. We evaluated HealthClaw with a synthetic year-long benchmark and nine 200-case biomedical tasks. Across 900 longitudinal support probes, answer accuracy increased from 0.2% with current-query prompting to 45.7% with HealthClaw, while prompt-side context exposure was 71.7% lower than with full-history prompting. In 100 privacy probes, HealthClaw produced higher privacy-aware answer quality and fewer unsafe disclosures than both baselines. Across the biomedical tasks, the mean absolute gain in the task-specific primary metric was 27.0 percentage points, and seven gains remained significant after false-discovery-rate correction. These offline benchmarks support governed, self-evolving memory for longitudinal personal health agents, although clinical effectiveness requires prospective evaluation. HealthClaw is publicly available at https://github.com/HC-Guo/HealthClaw.
Problem

Research questions and friction points this paper is trying to address.

longitudinal health management
personal health AI
health agent
continual learning
privacy-aware health support
Innovation

Methods, ideas, or system contributions that make the work stand out.

self-evolving agent
longitudinal health management
privacy-aware memory
inductive memory update
modular knowledge separation
Haoran Li
Haoran Li
University of Science and Technology of China
3D Generation 3D Editing 3D Understanding
J
Jiebi Deng
School of Data Science, Fudan University, Shanghai, China
T
Tong Jin
School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China
J
Jinghong Han
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China
Yuxin Wang
Yuxin Wang
Fudan University
Z
Zexin Wang
School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan, China
Q
Qingyi Si
JD.com, Inc., Beijing, China
Weikang Gong
Weikang Gong
Young Principal Investigator, School of Data Science, Fudan University;WIN, University of Oxford
Machine LearningDeep LearningMedical Image AnalysisBrain Imaging
Xiahai Zhuang
Xiahai Zhuang
Professor, School of Data Science, Fudan University
medical image analysisAI in MedicineInterpretabilityExplainable AI
J
Jia You
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China
Wei Cheng
Wei Cheng
Principal Investigator, ISTBI (类脑智能科学与技术与研究院), Fudan University
MRINeurosciencePsychiatryMachine learning
J
Jianfeng Feng
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China
Hongcheng Guo
Hongcheng Guo
School of Data Science, Fudan University
LLMsMultimodal LLMs