Learning to Discover at Test Time
This work proposes TTT-Discover, a novel approach that introduces test-time training (TTT) to scientific discovery by leveraging online reinforcement learning to optimize large language models during inference. Unlike conventional AI methods that rely solely on the generalization of pretrained models and struggle to autonomously identify optimal solutions at test time, TTT-Discover focuses on generating a single high-quality solution rather than improving average performance. Built upon the open-source model OpenAI gpt-oss-120b and augmented with a customized search subroutine and the Tinker API, the method achieves highly efficient and low-cost optimization. It sets new state-of-the-art results across diverse domains—including mathematical theorem proving, GPU kernel design, algorithmic competitions, and single-cell denoising—with all findings validated by domain experts or competition organizers at a cost of only a few hundred dollars per task.