Explainability in Generative Medical Diffusion Models: A Faithfulness-Based Analysis on MRI Synthesis
This study addresses the opacity of decision-making in generative diffusion models for medical MRI synthesis by introducing fidelity evaluation into the interpretability analysis of such models. The work proposes a novel interpretable framework that integrates denoising trajectories with prototype-based networks—including ProtoPNet, EPPNet, and ProtoPool—to elucidate the model’s underlying reasoning mechanisms. Experimental results demonstrate that the proposed approach, particularly when instantiated with EPPNet, achieves a fidelity score of 0.1534, significantly outperforming baseline methods. This advancement provides more reliable and transparent explanations of the generative process, thereby enhancing the safety and trustworthiness of medical AI systems.