Physically Aware Radiomics Without Interpolation: Disentangling Voxel Geometry and Signal Modification in CT and MRI
This study addresses the instability of conventional radiomics features in anisotropic CT/MRI images, which arises from conflating voxel geometry with signal alterations introduced by interpolation. To resolve this issue, the authors propose a voxel-spacing-aware radiomics framework that explicitly models the physical geometry of vox日晚间 through metadata, thereby decoupling intrinsic geometric structure from interpolation-induced distortions—all without image resampling or alteration of the original signal. Implemented within PyRadiomics, four configurations (NR, RS, VS, FK) were evaluated for robustness using intraclass correlation coefficients (ICC), Friedman tests, feature selection, and multilayer perceptron performance. Results demonstrate that the proposed VS method achieves near-perfect agreement with non-resampled baseline features in both CT and MRI (ICC > 0.997), delivers comparable predictive performance, and effectively circumvents resampling-related biases.