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Dickinson College

Academic institutionnorthamerica · us
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Research library3linked papers
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Selected work

Representative Papers

Cardinal Grid Slime Trail is PSPACE-Complete

Aug 05, 2026

This study resolves an open problem concerning the computational complexity of the grid-based Slime Trail puzzle game. Focusing on the cardinal four-directional variant, the authors establish its PSPACE-completeness by presenting a novel reduction from Quantified Boolean Formula (QBF), which introduces specialized gadgets that satisfy both parity and degree constraints inherent to the integer lattice. The construction leverages the regular structure of the grid and naturally extends—via a 45-degree rotation—to the eight-directional version. Consequently, this work proves that both predominant gameplay variants are PSPACE-complete, thereby filling a longstanding gap in the theoretical understanding of this classic puzzle game’s complexity landscape.

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CytoDINO: Risk-Aware and Biologically-Informed Adaptation of DINOv3 for Bone Marrow Cytomorphology

Dec 09, 2025

Morphological analysis of bone marrow cells is critical for diagnosing hematologic malignancies, yet manual interpretation is time-consuming, subjective, and entails asymmetric diagnostic risks—misclassifying blasts as normal cells poses significantly greater clinical harm than the reverse. To address this, we propose the first clinical risk-aware, lightweight pathological analysis framework. Our method introduces a Hierarchical Focal Loss (HFL) that incorporates lineage-specific biological priors to impose stronger penalties on high-risk misclassifications. It further integrates parameter-efficient fine-tuning via DINOv3-LoRA, confidence-driven selective prediction, and knowledge-guided modeling of inter-class relationships. Evaluated on the MLL dataset, our framework achieves 88.2% weighted F1 and 76.5% macro-F1 scores while training only 8% of parameters. It is deployable on a single RTX 5080 GPU, and its selective prediction mechanism covers 67% of samples with 99.5% accuracy.

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Recent publications

Latest Papers

Cardinal Grid Slime Trail is PSPACE-Complete

Aug 05, 2026

This study resolves an open problem concerning the computational complexity of the grid-based Slime Trail puzzle game. Focusing on the cardinal four-directional variant, the authors establish its PSPACE-completeness by presenting a novel reduction from Quantified Boolean Formula (QBF), which introduces specialized gadgets that satisfy both parity and degree constraints inherent to the integer lattice. The construction leverages the regular structure of the grid and naturally extends—via a 45-degree rotation—to the eight-directional version. Consequently, this work proves that both predominant gameplay variants are PSPACE-complete, thereby filling a longstanding gap in the theoretical understanding of this classic puzzle game’s complexity landscape.

0 citationsRead paper

CytoDINO: Risk-Aware and Biologically-Informed Adaptation of DINOv3 for Bone Marrow Cytomorphology

Dec 09, 2025

Morphological analysis of bone marrow cells is critical for diagnosing hematologic malignancies, yet manual interpretation is time-consuming, subjective, and entails asymmetric diagnostic risks—misclassifying blasts as normal cells poses significantly greater clinical harm than the reverse. To address this, we propose the first clinical risk-aware, lightweight pathological analysis framework. Our method introduces a Hierarchical Focal Loss (HFL) that incorporates lineage-specific biological priors to impose stronger penalties on high-risk misclassifications. It further integrates parameter-efficient fine-tuning via DINOv3-LoRA, confidence-driven selective prediction, and knowledge-guided modeling of inter-class relationships. Evaluated on the MLL dataset, our framework achieves 88.2% weighted F1 and 76.5% macro-F1 scores while training only 8% of parameters. It is deployable on a single RTX 5080 GPU, and its selective prediction mechanism covers 67% of samples with 99.5% accuracy.

0 citationsRead paper