Frequency Selection for the Diagnostic Characterization of Human Brain Tumours
Conventional magnetic resonance spectroscopy (MRS) full-spectrum analysis for noninvasive brain tumor diagnosis suffers from high spectral redundancy and weak discriminability, limiting diagnostic accuracy and interpretability. Method: This paper proposes a task-oriented adaptive frequency-point selection method that jointly optimizes with nonlinear classifiers (e.g., SVM or ANN) to automatically identify the most discriminative spectral regions from high-dimensional metabolic profiles. Unlike traditional fixed-bandwidth or full-spectrum modeling approaches, our method explicitly balances feature interpretability and classification performance. Contribution/Results: Evaluated on an international multicenter brain tumor MRS dataset, the proposed method significantly reduces redundant frequency-point interference and achieves superior classification accuracy compared to state-of-the-art methods. It delivers clinically actionable, interpretable, and highly accurate auxiliary diagnostic support for neuro-oncology.