Institution profile

Amsterdam University Medical Centers

Academic institutioneurope · nl
Official website
Research library15linked papers
Opportunities0open roles
Selected work

Representative Papers

leaspy: LEArning Spatiotemporal Patterns in PYthon

Aug 10, 2026

This work addresses the challenge of temporal misalignment in longitudinal data arising from inter-individual differences in the onset and progression rates of dynamic processes. To this end, the authors introduce leaspy, an open-source Python library based on mixed-effects models. The framework enables multivariate modeling of continuous, time-to-event, and mixed data types within a unified formulation, facilitating both population-level trajectory estimation and individual-specific deviation capture. A dedicated time-warping algorithm is incorporated to align heterogeneous longitudinal observations across subjects. Notably, this is the first implementation to integrate multivariate heterogeneous longitudinal modeling in a scalable and robust software architecture. The method has been successfully applied in neurodegenerative disease research, where it effectively characterizes disease heterogeneity and yields accurate personalized predictions, demonstrating its practical utility and validity.

0 citationsRead paper
Recent publications

Latest Papers

leaspy: LEArning Spatiotemporal Patterns in PYthon

Aug 10, 2026

This work addresses the challenge of temporal misalignment in longitudinal data arising from inter-individual differences in the onset and progression rates of dynamic processes. To this end, the authors introduce leaspy, an open-source Python library based on mixed-effects models. The framework enables multivariate modeling of continuous, time-to-event, and mixed data types within a unified formulation, facilitating both population-level trajectory estimation and individual-specific deviation capture. A dedicated time-warping algorithm is incorporated to align heterogeneous longitudinal observations across subjects. Notably, this is the first implementation to integrate multivariate heterogeneous longitudinal modeling in a scalable and robust software architecture. The method has been successfully applied in neurodegenerative disease research, where it effectively characterizes disease heterogeneity and yields accurate personalized predictions, demonstrating its practical utility and validity.

0 citationsRead paper