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Cold Spring Harbor Laboratory

Academic institutionnorthamerica · us
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Research library2linked papers
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Selected work

Representative Papers

DataParasite Enables Scalable and Repurposable Online Data Curation

Jan 05, 2026arXiv.org

This work proposes an open-source, modular data collection pipeline to address the labor-intensive, costly, and poorly reproducible nature of dataset construction from heterogeneous online sources in computational social science. The system employs lightweight natural language instructions to configure workflows, decomposing tabular data curation into entity-level search and structured extraction tasks. By leveraging large language model–based intelligent agents, it achieves a task-agnostic, reusable architecture that operates effectively even without predefined entity lists. Evaluated across multiple representative tasks, the approach attains high accuracy while reducing data acquisition costs by an order of magnitude compared to manual methods, substantially lowering both technical and human resource barriers to entry.

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Walking the Weight Manifold: a Topological Approach to Conditioning Inspired by Neuromodulation

May 29, 2025

This work addresses multi-task learning by proposing a neuro-modulation-inspired approach to dynamic parameter modeling. Instead of conventional context-conditioning via input concatenation, it constructs smooth manifolds—endowed with predefined topologies (e.g., line, ellipse, torus)—directly in weight space, enabling continuous parameter evolution across tasks. It is the first to formalize neural modulation as a manifold-constrained optimization problem, leveraging topological priors to guide task relationship modeling and generalization. The method integrates variational manifold optimization, constraint-aware volume-minimization loss, and low-dimensional implicit weight parameterization. Experiments demonstrate that linear and elliptical manifolds significantly outperform input-concatenation baselines in noise robustness and image rotation generalization, while also improving out-of-distribution accuracy.

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Recent publications

Latest Papers

DataParasite Enables Scalable and Repurposable Online Data Curation

Jan 05, 2026arXiv.org

This work proposes an open-source, modular data collection pipeline to address the labor-intensive, costly, and poorly reproducible nature of dataset construction from heterogeneous online sources in computational social science. The system employs lightweight natural language instructions to configure workflows, decomposing tabular data curation into entity-level search and structured extraction tasks. By leveraging large language model–based intelligent agents, it achieves a task-agnostic, reusable architecture that operates effectively even without predefined entity lists. Evaluated across multiple representative tasks, the approach attains high accuracy while reducing data acquisition costs by an order of magnitude compared to manual methods, substantially lowering both technical and human resource barriers to entry.

0 citationsRead paper

Walking the Weight Manifold: a Topological Approach to Conditioning Inspired by Neuromodulation

May 29, 2025

This work addresses multi-task learning by proposing a neuro-modulation-inspired approach to dynamic parameter modeling. Instead of conventional context-conditioning via input concatenation, it constructs smooth manifolds—endowed with predefined topologies (e.g., line, ellipse, torus)—directly in weight space, enabling continuous parameter evolution across tasks. It is the first to formalize neural modulation as a manifold-constrained optimization problem, leveraging topological priors to guide task relationship modeling and generalization. The method integrates variational manifold optimization, constraint-aware volume-minimization loss, and low-dimensional implicit weight parameterization. Experiments demonstrate that linear and elliptical manifolds significantly outperform input-concatenation baselines in noise robustness and image rotation generalization, while also improving out-of-distribution accuracy.

0 citationsRead paper