Interpretability-Aware Pruning for Efficient Medical Image Analysis
Deep neural models for medical image analysis suffer from excessive parameter counts and poor interpretability, hindering clinical deployment. To address this, we propose an interpretability-aware structured pruning framework that—uniquely—leverages attribution methods (DL-Backprop, LRP, and Integrated Gradients) as dynamic pruning guidance signals. These signals identify and preserve neuron-level components critical for clinical diagnosis, enabling simultaneous model compression and joint optimization of predictive performance and decision transparency. Evaluated across multiple medical image classification benchmarks, our method achieves aggressive pruning (>50% parameter reduction) with negligible accuracy degradation (<0.5% drop), while substantially improving inference efficiency and interpretability. The framework establishes a novel paradigm for deploying lightweight, trustworthy AI models in clinical settings.