FedDOSE: Federated Learning Framework Decomposing Site Effects for Modeling Brain Dynamic Functional Connectivity
This work addresses the challenge of site-induced statistical heterogeneity in multi-site fMRI data within federated learning, a problem exacerbated by the frequent neglect of the brain’s dynamic functional characteristics. To this end, the authors propose FedDOSE, a novel framework that jointly models dynamic functional connectivity (dFC) and site heterogeneity for the first time in a federated setting. FedDOSE efficiently encodes high-dimensional dFC tensors via module-guided Tucker decomposition and aligns cross-site class prototypes through an integration of optimal transport centroids and Procrustes analysis. Evaluated on the ABIDE-I, ABIDE-II, and ADHD-200 datasets, the method demonstrates superior performance over existing approaches, exhibiting enhanced generalization and robustness in diagnostic tasks for autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD).